Method of studying depth distribution of therapeutic and diagnostic substances inside spherical amorphous nanoparticles

Autor:	A. P. Kaplun, L. I. Boguslavsky, Vitaliy Khlebnikov, Vladimir I. Popenko, V. I. Shvets
Rok vydání:	2010
Předmět:	Materials science Substance Distribution General Engineering Analytical chemistry Nanoparticle Optical density Condensed Matter Physics Amorphous solid Solvent Triterpenoid Chemical engineering General Materials Science Solubility Mass fraction
Zdroj:	Nanotechnologies in Russia. 5:709-714
ISSN:	1995-0799 1995-0780
DOI:	10.1134/s1995078010090156
Popis:	A method for investigating the distribution of therapeutic and diagnostic substances inside nanoparticles was developed for spherical amorphous nanoparticles (SANPs). SANPs were generated from the lupan triterpenoids of birch bark (LTs). This method was based on the sequence of short exposures of SANPs in a special solvent. The thin surface layers of the main material and the material of substances incorporated into the SANPs were dissolved. The distribution of three different substances in the SANPs were analyzed by determining the optical density of the solutions containing material extracted from SANPs. It was shown that the distribution of therapeutic and diagnostic substances in SANPs depended on their solubility in the solution saturated with the main SANPs material and their mass fraction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c4c8ede5c4862d5d9728af865f0b1de9 https://doi.org/10.1134/s1995078010090156 Zobrazit plný text záznamu Full text from SpringerLink