Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability and Risk of Cardiovascular Outcomes
| Autor: | Andrei Breazna, Franz H. Messerli, Chuan-Chuan Wun, Sripal Bangalore, David A. DeMicco, Investigators |
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| Rok vydání: | 2015 |
| Předmět: |
Ldl cholesterol
medicine.medical_specialty Statin business.industry medicine.drug_class Low density lipoprotein cholesterol Atorvastatin 80 MG Independent predictor medicine.disease Surgery Coronary artery disease Internal medicine medicine Cardiology lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Cardiovascular outcomes Lipoprotein cholesterol |
| Zdroj: | Journal of the American College of Cardiology. 65:1539-1548 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2015.02.017 |
| Popis: | Background Studies demonstrate that lowering low-density lipoprotein cholesterol (LDL-C) using a statin is associated with significant reduction in cardiovascular events. Whether visit-to-visit variability in LDL-C levels affects cardiovascular outcomes is unknown. Objectives This study sought to evaluate the role of visit-to-visit variability in LDL-C levels on cardiovascular outcomes. Methods We evaluated patients with coronary artery disease and LDL-C Results Among 9,572 patients, SD and ASV were significantly lower with atorvastatin 80 mg/day versus 10 mg/day (SD: 12.03 ± 9.70 vs. 12.52 ± 7.43; p = 0.005; ASV: 12.84 ± 10.48 vs. 13.76 ± 8.69; p Conclusions In subjects with coronary artery disease, visit-to-visit LDL-C variability is an independent predictor of cardiovascular events. |
| Databáze: | OpenAIRE |
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