Prostaglandine und Prostaglandinvorstufen. VIII. Synthese von (1S, 5S)-5-Methyl-2-oxa-bicyclo[3.3.0]octan-3,6-dion, einem wichtigen Zwischenprodukt für 8-Methyl-prostaglandin C2

Autor:	H. Schick, S. Schwarz, H.-P. Welzel
Rok vydání:	1983
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Acetic acid chemistry Bicyclic molecule Stereochemistry Prostaglandin Stereoselectivity Complex metal hydride Lactone
Zdroj:	Journal für Praktische Chemie. 325:529-533
ISSN:	0021-8383
DOI:	10.1002/prac.19833250402
Popis:	Prostaglandins and Prostaglandin Intermediates. VIII. Synthesis of (1S, 5S)-5-Methyl-2-oxa-bicyclo[3.3.0]octane-3,6-dione, an Important Intermediate for 8-Methylprostaglandin C2 The bicyclic lactone 5 is prepared by Meerwein-Ponndorf-Verley-reduction of the chiral cyclopentyl acetic acid 3. The stereoselectivity of this reaction is compared with that of complex metal hydride reductions.
Databáze:	OpenAIRE
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