EARLY IMPROVEMENT IN CARDIAC FUNCTION OCCURS FOR PANCREAS-KIDNEY BUT NOT DIABETIC KIDNEY-ALONE TRANSPLANT RECIPIENTS
| Autor: | D. S. Elmer, A O Gaber, M. H. Shokouh-Amiri, Soliman El-Gebely, Brad S. Burlew, Robert B. Mccully, Prasanna Sugathan, Donna Hathaway |
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| Rok vydání: | 1995 |
| Předmět: |
Cardiac function curve
Transplantation medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Diastole Pancreas transplantation Doppler echocardiography medicine.disease Surgery Internal medicine Diabetes mellitus Cardiology Medicine Systole business Kidney transplantation |
| Zdroj: | Transplantation. 59:1105-1112 |
| ISSN: | 0041-1337 |
| Popis: | Noninvasive M mode echocardiography with Doppler recording was prospectively performed on type I diabetic recipients of pancreas-kidney (n = 20), pancreas-after-kidney (n = 2), and kidney-alone (n = 11) allografts to determine whether the return of euglycemia by pancreas transplantation in the uremic diabetic person was associated with improved cardiac function. Each patient was studied preoperatively and at 6 and 12 months posttransplant. Echocardiographic parameters which were compared included measures of systolic function (shortening fraction), diastolic function (early/active peak velocity ratio, early/active integral ratio), and left ventricular geometric parameters (interventricular septal thickness, posterior wall thickness, left ventricular mass). The only statistically significant improvement observed for kidney-alone recipients was an increased shortening fraction from baseline (24.91%) to 6 months (32.13%, P < or = 0.0188). In contrast, the pancreas group demonstrated sustained improvement in all outcomes with measures at 12 months consistently showing a significant improvement from baseline which was also significantly better than that reported for the kidney-alone group. This study showed stabilization of cardiac function by echocardiography for diabetic kidney-alone recipients, whereas significant improvement in function occurred for pancreas-kidney recipients. The improvement in cardiac function for pancreas recipients was seen at 6 months with continued improvement evident at 12 months. |
| Databáze: | OpenAIRE |
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