ChemInform Abstract: Synthesis and Antitumor Activity of N-Acetylmuramyl-L-alanyl-D-isoglutamine 6-Phosphate and Its Lipophilic Derivatives

Autor:	Morihiro Kohno, Akiko Tohgo, Shigeki Kageyama, Shoichi Kusumoto, Kensuke Matsumoto, Masahiro Imoto, Shinjiro Hashimoto, Tetsuo Shiba
Rok vydání:	1987
Předmět:	carbohydrates (lipids) Antitumor activity chemistry.chemical_compound chemistry Stereochemistry N-Acetylmuramyl-L-Alanyl-D-Isoglutamine Tumor regression General Medicine Phosphate Muramyl dipeptide Mycobacterial cell
Zdroj:	ChemInform. 18
ISSN:	0931-7597
DOI:	10.1002/chin.198711309
Popis:	6-Phosphate of N-acetylmuramyl-L-alanyl-D-isoglutamine and its lipophilic derivatives, i.e., 6-(octadecyl hydrogenphosphate) and 6-(2-docosyltetracosyl hydrogenphosphate) were synthesized after the structural feature of mycobacterial cell walls for the purpose to modify and possibly to enhance the immunostimulating activity of the muramyl dipeptide which is the minimum requisite for the activity. As expected, the latter more lipophilic phosphate showed a high activity in a tumor regression test.
Databáze:	OpenAIRE
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