Synthesis and characterization of cellulose-acetanilide ether and its antibacterial activity
| Autor: | Mohammed El Moussaouiti, Ahmed Talbaoui, Lahcen El Hamdaoui |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Polymers and Plastics Chemical structure Ether 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Microcrystalline cellulose chemistry.chemical_compound Microcrystalline chemistry Materials Chemistry Organic chemistry Cellulose 0210 nano-technology Antibacterial activity Acetanilide Kraft paper |
| Zdroj: | Polymer Bulletin. 75:2401-2413 |
| ISSN: | 1436-2449 0170-0839 |
| DOI: | 10.1007/s00289-017-2164-2 |
| Popis: | This study examined the preparation, characterization, and antibacterial activity of cellulose-acetanilide. Cellulose-acetanilide ethers were prepared by homogeneous etherification of microcrystalline or kraft cellulose with 2-Chloroacetanilide in LiCl/DMAc (8%) at 60 °C for 24 h under mild reaction conditions. The 2-Chloroacetanilide could highly efficiently react with cellulose to synthesize cellulose-acetanilide ethers with controllable degree of substitution (DS). DS was in a range of 0.2–1.5 adjusted by the molar ratio of 2-Chloroacetanilide to anhydroglucose unit. The DS of microcrystalline cellulose is significantly higher than that of the kraft cellulose. The chemical structure and properties of the obtained products were characterized by FT-IR, NMR, and SEM. The antibacterial activity of the synthesized compounds were screened against the representative bacterium Rhodococcus sp. GK1, by the agar well diffusion method, and compared with commercials antibiotic such as Cephalothin, Ampicillin, Amoxicillin, Chloramphenicol, Kanamycin and Doxycycline. It was found that antibacterial experiment revealed excellent antibacterial activity of the cellulose-acetanilide ethers. |
| Databáze: | OpenAIRE |
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