ChemInform Abstract: Propargylamine-Isothiocyanate Reaction: Efficient Conjugation Chemistry in Aqueous Media

Autor:	Helene Marie-France Viart, Mads Hartvig Clausen, Thomas Lars Andresen, Chiara Tassone, T. S. Larsen
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Liposome Ether lipid chemistry Aqueous medium Isothiocyanate Propargyl Organic chemistry General Medicine Conjugated system POPC Coupling reaction
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201451156
Popis:	A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c485574eaa75a07039f5211e9b84591a https://doi.org/10.1002/chin.201451156 Zobrazit plný text záznamu Plný text