Green synthesis of nano sized transition metal complexes containing heterocyclic Schiff base: Structural and morphology characterization and bioactivity study
| Autor: | Sangamesh A. Patil, Shailaja S. Jawoor, Mahantesh Kumbar, Prashant B. Ramawadgi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Schiff base 010405 organic chemistry Ligand Organic Chemistry Carbon-13 NMR 010402 general chemistry 01 natural sciences 0104 chemical sciences Analytical Chemistry Coordination complex Inorganic Chemistry Metal chemistry.chemical_compound Crystallography chemistry Transition metal visual_art visual_art.visual_art_medium Spectroscopy Powder diffraction |
| Zdroj: | Journal of Molecular Structure. 1164:378-385 |
| ISSN: | 0022-2860 |
| Popis: | In the current involvement of our research work in coordination chemistry, novel transition metal complexes were synthesized from regular reflux method and hydrothermal method using Schiff base prepared via condensation of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate with 8-carbaldehyde-7-hydroxy-4-methylcoumarin. All the synthesized compounds were interpreted using different analytical, physicochemical and spectral methods such as magnetic moment measurement, FT-IR, 1H and 13C NMR, GCMS/ESI-MS, UV/Vis spectroscopy and TGA. The size and morphology of the nano metal complexes were determined using atomic force microscope (AFM), field emission scanning electron spectroscopy (FE-SEM) and X-ray powder diffraction (PXRD). The non-electrolytic nature of the metal complexes was confirmed by molar conductance studies. The obtained FT-IR data supports the binding of metal ion to Schiff base. Elemental analysis study suggests [ML2(H2O)2] stoichiometry, here M = Co(II), Ni(II) and Cu(II), L = deprotonated ligand. Electronic spectral results reveal six-coordinated geometry for the synthesized metal complexes. All the tested compounds show good DNA cleavage (Calf Thymus DNA) and in vitro anticancer activity (PA-I cell line), the activity results for the tested compounds are prominent and compound 9 exhibited a little enhanced activity than the other tested compounds. |
| Databáze: | OpenAIRE |
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