Prevention of Nephropathy by Some Natural Sources of Antioxidants
| Autor: | Mohamed Omar Albasha, Azab Elsayed Azab, Ata Sedik Ibrahim Elsayed |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Kidney
Antioxidant business.industry medicine.medical_treatment CCL4 Pharmacology Propolis medicine.disease Nephrotoxicity Nephropathy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis medicine Curcumin business Sodium nitrite 030217 neurology & neurosurgery |
| Zdroj: | Yangtze Medicine. :235-266 |
| ISSN: | 2475-7349 2475-7330 |
| DOI: | 10.4236/ym.2017.14023 |
| Popis: | Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin. Natural sources of antioxidants may serve as a vital source of potentially useful new compounds for the development of an effective therapy to combat a variety of kidney problems. Natural antioxidants have a variety of biochemical actions such as inhibition of reactive oxygen species production, scavenging of free radicals. The present review aims to summarize the recent articles which studied some of the nephrotoxic agents, and alleviation of nephrotoxicity using of some natural products possessing antioxidant properties. Our review shows the oxidative damage and renal disorders induced in human and experimental animals by nephrotoxic agents such as gentamicin, alcohol, nicotine, adenine, glycerol, ethylene glycol, sodium nitrite, mercuric chloride, AlCl3, lead acetate, carbon tetrachloride (CCl4), furosemide, carbendazim, diazinon, heat stress, and γ-radiation. Also, nephrotic disorders caused in diabetic rats, patients, cirrhotic ascetic patients, and ischemia-reperfusion. Administration of natural sources of antioxidants such as curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame attenuated both physiological and histopathological alterations induced in the kidney by the nephrotoxic agent and certain diseases. The nephroprotective effect of the former natural sources of antioxidants may be due to the enhancement of antioxidant activity and inhibition of tissue lipid peroxidation. It can be concluded that administration of curcumin, garlic, fenugreek, parsley, peppermint, pomegranate, propolis, olive leaves, rosemary, and sesame showed a remarkable kidney protection against nephrotoxic agents, and diseases induced renal dysfunctions in human and experimental animals. So, the present study recommended that the consumption of these natural sources of antioxidants may be useful for human exposure to nephrotoxic agents and patients who suffer from renal diseases. |
| Databáze: | OpenAIRE |
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