Membranous Glomerulonephritis in WiskottAldrich syndrome
| Autor: | Yasuo Takekoshi, Yukio Sakiyama, Tadashi Ariga, Hiromi Tsuneta, Yutaka Takahashi, Tohru Watanabe, Toshiaki Ishii, Shuzo Matsumoto |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.diagnostic_test
Wiskott–Aldrich syndrome business.industry Glomerulonephritis medicine.disease medicine.disease_cause Epstein–Barr virus Immune complex hemic and lymphatic diseases Pediatrics Perinatology and Child Health Humoral immunity Immunology medicine Renal biopsy business Nephrotic syndrome Nephritis |
| Zdroj: | Pediatrics International. 28:226-231 |
| ISSN: | 1442-200X 1328-8067 |
| DOI: | 10.1111/j.1442-200x.1986.tb00721.x |
| Popis: | 15-year-old boy with Wiskott-aldrich syndrome (WAS) associated with nephrotic syndrome was reported. Histological findings on a renal biopsy specimen by light, fluorescence and electron mictroscopies disclosed pathologic changes typical of mambranous glomerulonephritis. He had an abnormalityin cellular and humoral immunity, i.e. decreased delayed type hypersensitivity, low level of IgM and high level of IgE, and was suspected to have a persistent Epstein Barr virus (EBV) infection. Since membranous glomerulonephritis is one of the immune complex types if nephritis, we attempted to demonstrate EBV in the renal tissue but could not confirm its presence. Nephritis is not common;y associated wioth WAS. However, the prolonged survival through improved medical management may allow the more frequent development of renal diseases. Attention should therefore be paid to the appearance of renal maniofestation in patients with WAS. |
| Databáze: | OpenAIRE |
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