Pharmacological effects at the chronic administration of Melilotus officinalis L. extract
| Autor: | E. V. Schepetova, E. I. Kondratenko, N. A. Lomteva, S. K. Kasimova, N. M. Abdurakhmanova |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | IOP Conference Series: Earth and Environmental Science. 839:042100 |
| ISSN: | 1755-1315 1755-1307 |
| DOI: | 10.1088/1755-1315/839/4/042100 |
| Popis: | We studied the chemical composition and pharmacological effects of Melilotus officinalis L. after chronic administration to male rats. In Melilotus officinalis L. contains flavonoids, polysarides, triterpene saponins, ascorbic acid, coumarins, tannins. To study the pharmacological action, a biochemical analysis of blood and urine, a hematological blood test, a study of the coagulation system and behavioral properties in the Suok test were carried out. Chronic administration of the Melilotus officinalis L. extract led to a decrease in patterns of orientation-exploratory behavior, an increase in the level of anxiety. The activity of such enzymes as AST and alkaline phosphatase under long-term administration of the Melilotus officinalis L. significantly increased, while the activity of ALT decreased, in addition, there was a significant increase in blood coagulation. Thus, chronic administration of the extract to laboratory animals for 21 days revealed its toxic effect, manifested in liver disorders, changes in the blood coagulation system, and a decrease in pattern-research behavior. |
| Databáze: | OpenAIRE |
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