SLCO1B1 gene-based clinical decision support reduces statin-associated muscle symptoms risk with simvastatin

Autor:	Amanda Massmann, Joel Van Heukelom, Robert C Green, Catherine Hajek, Madison R Hickingbotham, Eric A Larson, Christine Y Lu, Ann Chen Wu, Emilie S Zoltick, Kurt D Christensen, April Schultz
Rok vydání:	2023
Předmět:	Pharmacology Genetics Molecular Medicine
Zdroj:	Pharmacogenomics.
ISSN:	1744-8042 1462-2416
Popis:	Background: SLCO1B1 variants are known to be a strong predictor of statin-associated muscle symptoms (SAMS) risk with simvastatin. Methods: The authors conducted a retrospective chart review on 20,341 patients who had SLCO1B1 genotyping to quantify the uptake of clinical decision support (CDS) for genetic variants known to impact SAMS risk. Results: A total of 182 patients had 417 CDS alerts generated, and 150 of these patients (82.4%) received pharmacotherapy that did not increase risks for SAMS. Providers were more likely to cancel simvastatin orders in response to CDS alerts if genotyping had been done prior to the first simvastatin prescription than after (94.1% vs 28.5%, respectively; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c458f716a00b585c020dc1d585211357 https://doi.org/10.2217/pgs-2023-0056 Zobrazit plný text záznamu