Stereospecific Iron-Catalyzed Carbon (sp2)–Carbon (sp2) Cross-Coupling of Aryllithium with Vinyl Halides

Autor:	Zhi-Yong Wang, Henry N. C. Wong, Peng Chen, Xiao-Shui Peng
Rok vydání:	2021
Předmět:	Coupling 010405 organic chemistry Chemistry Iron catalyzed Organic Chemistry Halide chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Stereospecificity Organolithium compounds Physical and Theoretical Chemistry Carbon
Zdroj:	Organic Letters. 23:4385-4390
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c01318
Popis:	We present herein an efficient synthetic protocol involving iron-catalyzed cross-coupling of organolithium compounds with vinyl halides as key coupling partners. More than 30 examples were obtained with moderate to good yields and high stereoselectivities. The practicality of this method is evidenced by a gram-scale synthesis. In addition, a preliminary mechanistic investigation was also performed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c455db5f6ca968913d0ab7ec2ebd42d1 https://doi.org/10.1021/acs.orglett.1c01318 Zobrazit plný text záznamu