Opioids as Triggers of the Adaptive Phenomenon of Ischemic Preconditioning of the Heart
| Autor: | Yu. K. Podoksenov, S. Yu. Tsibulnikov, N. V. Naryzhnaya, Mrochek Ag, A. S. Gorbunov, Leonid N. Maslov |
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| Rok vydání: | 2016 |
| Předmět: |
Enkephalin
business.industry General Neuroscience 030204 cardiovascular system & hematology Pharmacology In vitro Blockade 03 medical and health sciences 0302 clinical medicine Opioid In vivo Anesthesia Medicine Ischemic preconditioning business Opioid peptide Receptor 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 46:319-327 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-016-0236-7 |
| Popis: | Transient ischemia/reperfusion has been shown to evoke increases in enkephalin levels in myocardial tissue. Blockade of δ opioid receptors eliminates the cardioprotective effect of ischemic preconditioning both in vivo and in vitro. Inhibition of κ1 opioid receptors eliminates the cardioprotective effect of preconditioning only in vitro. Agonists of μ, δ1, δ2, and κ1 opioid receptors imitate the cardioprotective effect of preconditioning. These results indicate that endogenous opioid peptides are triggers of ischemic preconditioning. |
| Databáze: | OpenAIRE |
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