| Autor: |
Jean Oustrin, Alain Romecki |
| Rok vydání: |
1985 |
| Předmět: |
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| Zdroj: |
International Journal of Cosmetic Science. 7:29-35 |
| ISSN: |
0142-5463 |
| DOI: |
10.1111/j.1467-2494.1985.tb00392.x |
| Popis: |
Resume L'activite antiseborrheique de la sebathionine a eteetudiee sur la glande costovertebrale de hamster mâle castre et supplemente en testosterone. Le test utilise est l'incorporation de precurseurs marques de la synthese lipidique. Le glucose comme l'acetate de sodium voient leur vitesse d'incorporation diminuer sous l'influence de la sebathionine. L'emploi d'un faux precurseur: le deoxyglucose montre que le produit agit de facon non specifique sur la synthese lipidique. Cependant, au niveau de la synthese des acides gras, on peut preciser que l'action se situe au niveau des mecanismes d'allongement des chaines carbonees et non au niveau des processus de desaturation. Activity and mechanism of sebathionine (D.C.I.) on sebum formation Synopsis An experimental study of seborrheic sebathionine activity has been carried out on the flank organ of castrated and testosterone-treated hamsters. Lipid synthesis is followed by the incorporation of labelled precursors. Sebathionine decreases the incorporation of both glucose and sodium acetate to the same extent in the lipids of the sebaceous gland. The non-specific nature of this inhibition has been shown by the decrease in the rate of incorporation of a similar non-precursor molecule deoxyglucose. The effect of the sebathionine appears to be an inhibition of the lengthening of the fatty chains rather than the inhibition of unsaturation of the fats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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