Antibodies to Merkel cells in human sera

Autor:	L. Didierjean, F. Faucher, Yves Merot, P. Chavaz, J.-H. Saurat
Rok vydání:	1984
Předmět:	Pathology medicine.medical_specialty biology business.industry Monoclonal igm Pemphigus vulgaris Chronic cold agglutinin disease Dermatology Disease medicine.disease medicine.anatomical_structure Hematologic disorders Immunology biology.protein Medicine Antibody business Merkel cell
Zdroj:	Journal of the American Academy of Dermatology. 11:568-575
ISSN:	0190-9622
DOI:	10.1016/s0190-9622(84)70207-6
Popis:	Antibodies to Merkel cells (MC) are not known to occur in human sera. Using a newly described technic, we looked for the presence of antibodies directed against skin structures in sera from 2,300 patients with various dermatologic and hematologic disorders, as well as graft-versus-host disease (GVHD). Three of these sera (0.1%) were found to react with MC. One monoclonal IgM antibody was present in serum obtained from a patient with chronic cold agglutinin disease, the second from a patient with GVHD, and the third from a patient with pemphigus vulgaris. The present inadequate knowledge about normal MC function and the absence of described symptoms of MC dysfunction preclude analysis of the pathogenic significance of these MC antibodies in human sera.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c4437b54a34e0445baf2c8e6062ff17c https://doi.org/10.1016/s0190-9622(84)70207-6 Zobrazit plný text záznamu