GW28-e0155 Decrease Lean Mass and Increase Fat Mass of SGA Adult Rats Associated with Down-Regulation of the mTOR/S6K Pathway in Skeletal Muscle
| Autor: | Linxia Deng, Chuyi Guo, Zhenyu Shen, Muxue Yu, Xiaoshan Qiu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Kinase business.industry Insulin medicine.medical_treatment Skeletal muscle P70-S6 Kinase 1 Endocrinology medicine.anatomical_structure Downregulation and upregulation Internal medicine Ribosomal protein s6 medicine Phosphorylation Cardiology and Cardiovascular Medicine business PI3K/AKT/mTOR pathway |
| Zdroj: | Journal of the American College of Cardiology. 70:C184 |
| ISSN: | 0735-1097 |
| Popis: | Small for gestational age (SGA) is linked to increased risk of obesity and metabolic disorders in adulthood. Amino acids and insulin stimulate protein synthesis through mammalian target of rapamycin (mTOR) signaling pathway. Phosphorylation of ribosomal protein S6 kinase (S6K) is the effector of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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