Lessons from the Embryo: an Unrejected Transplant and a Benign Tumor
| Autor: | Maryam Dehghanian, Alaleh Rezalotfi, Nima Rezaei, Angelos Varotsos Vrynas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pregnancy business.industry Cancer Embryo Bioinformatics medicine.disease Benign tumor Transplant rejection Transplantation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system 030220 oncology & carcinogenesis medicine Stem cell business |
| Zdroj: | Stem Cell Reviews and Reports. 17:850-861 |
| ISSN: | 2629-3277 2629-3269 |
| DOI: | 10.1007/s12015-020-10088-5 |
| Popis: | Embryogenesis is regarded the 'miracle of life', yet numerous aspects of this process are not fully understood. As the embryo grows in the mother's womb, immune components, stem cells and microenvironmental cues cooperate among others to promote embryonic development. Evidently, these key players are frequently associated with transplantation failure and tumor growth. While the fields of transplantation and cancer biology do not overlap, both can be viewed from the perspective of an embryo. As an 'unrejected transplant' and a 'benign tumor', lessons from embryonic development may reveal features of transplants and tumors that have been overlooked. Therefore, eavesdropping at these natural complex events during pregnancy may inspire more durable approaches to arrest transplant rejection or cancer progression. |
| Databáze: | OpenAIRE |
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