Contribution of functional IL-18 promoter polymorphisms to the risk of idiopathic recurrent spontaneous miscarriage (117.29)

Autor:	Ghada Al-Khateeb, Mai Sater, Wassim Almawi
Rok vydání:	2011
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 186:117.29-117.29
ISSN:	1550-6606 0022-1767
Popis:	Interleukin (IL)-18 is a proinflammatory cytokine, which modulates Th1 differentiation and CTL effector activity, both of which were implicated in the pathogenesis of recurrent spontaneous miscarriage (RSM). We evaluate the association of single nucleotide polymorphisms (SNPs) in the IL18 gene promoter at -656G/T (rs1946519),-137G/C (rs187238), -119T/G (rs360718), and -105T/C (rs360717), were detected by TaqMan assays in analysis in 277 RSM cases and 283 control women matched for age and ethnic background; serum IL-18 level was measured by ELISA. Association of IL-18 alleles, genotypes, and haplotypes with RSM were evaluated by Fisher's exact test and regression analysis. The -656T (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c43ae25677c7a964c5eafc0ab65997c9 https://doi.org/10.4049/jimmunol.186.supp.117.29 Zobrazit plný text záznamu