Quantitative Assessment of Cardiac Hypermetabolism and Perfusion for Diagnosis of Cardiac Sarcoidosis
| Autor: | John D. Friedman, Payam Pournazari, Jignesh Patel, Louise Thomson, Piotr J. Slomka, Sean W. Hayes, Evan P. Kransdorf, Daniel S. Berman, Adele Pope, Michele A. Hamilton, Sebastien Cadet, Robert J.H. Miller, Balaji Tamarappoo |
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| Rok vydání: | 2020 |
| Předmět: |
Receiver operating characteristic
medicine.diagnostic_test business.industry Standardized uptake value Cardiac sarcoidosis 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Positron emission tomography Quantitative assessment Hypermetabolism medicine Radiology Nuclear Medicine and imaging Cardiology and Cardiovascular Medicine business Nuclear medicine Perfusion Kappa |
| Zdroj: | Journal of Nuclear Cardiology. 29:86-96 |
| ISSN: | 1532-6551 1071-3581 |
| Popis: | Quantitative assessment of cardiac hypermetabolism from 18Flourodeoxy glucose (FDG) positron emission tomography (PET) may improve diagnosis of cardiac sarcoidosis (CS). We assessed different approaches for quantification of cardiac hypermetabolism and perfusion in patients with suspected CS. Consecutive patients undergoing 18FDG PET assessment for possible CS between January 2014 and March 2019 were included. Cardiac hypermetabolism was quantified using maximal standardized uptake value (SUVMAX), cardiometabolic activity (CMA) and volume of inflammation, using relative thresholds (1.3× and 1.5× left ventricular blood pool [LVBP] activity), and absolute thresholds (SUVMAX > 2.7 and 4.1). Diagnosis of CS was established using the Japanese Ministry of Health and Wellness criteria. In total, 69 patients were studied, with definite or possible CS in 29(42.0%) patients. CMA above 1.5× LVBP SUVMAX had the highest area under the receiver operating characteristic curve (AUC 0.92). Quantitative parameters using relative thresholds had higher AUC compared to absolute thresholds (p |
| Databáze: | OpenAIRE |
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