Study of the HLA class II allele polymorphism and phylogenetic analysis in Vojvodina population

Autor: D. Ademović-Sazdanić, S. Vojvodić
Rok vydání: 2011
Předmět:
Zdroj: Russian Journal of Genetics. 47:364-368
ISSN: 1608-3369
1022-7954
DOI: 10.1134/s1022795411030197
Popis: The polymorphism at the HLA DRB1 and DQB1 loci in the population of Vojvodina was studied by PCR-SSP method. A total of 13 DRB1 and 5 DQB1 specificities displaying population-specific frequency distribution pattern were described. The most frequent HLA Class II alleles in Vojvodina population were: HLA-DRB1*11 (af = 0.30), −DRB1*04 (af = 0.28), −DRB1*07 (af = 0.21), −DRB1*13 and −DRB1*16 (af = 0.18), −DQB1*03 (af = 0.64), −DQB1*05 (af = 0.39) and −DQB1*02 (af = 0.35). The haplotypes with high frequencies (≥0.02) included HLA DRB1*11 DQB1*03 (0.0825), DRB1*04DQB1*03 (0.0725), DRB1*07DQB1*02 (0.0475). The allele DRB1*07 showed the strongest association with DQB1*02 (Δ = 0.0261, gC2 = 4.437) and DRB1*13 allele with DQB1*06 (Δ = 0.0222, gC2 = 4.247). The allelic frequencies and populations distance dendrogram revealed the closest relationship of Vojvodina population with Hungarians, Croat, and Greeks which can be the result of turbulent migration within this region and admixture with neighbour populations during the history.
Databáze: OpenAIRE
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