Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction
| Autor: | Daniel Rukavina, D. Travica Samsa, Viktor Peršić, Bojan Miletić, Rajko Miskulin, V. Pehar Pejcinovic, Gordana Laškarin, Alen Ruzic, Marijana Rakić, Damir Raljević |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test medicine.drug_class business.industry Lymphocyte Immunology General Medicine medicine.disease Natural killer T cell Monoclonal antibody medicine.disease_cause Autoimmunity medicine.anatomical_structure Endocrinology Perforin Internal medicine medicine biology.protein Myocardial infarction Cytotoxicity business Electrocardiography |
| Zdroj: | Scandinavian Journal of Immunology. 74:195-204 |
| ISSN: | 0300-9475 |
| DOI: | 10.1111/j.1365-3083.2011.02554.x |
| Popis: | The aim of this investigation was to examine the role of perforin (P)-mediated cytotoxicity in the dynamics of tissue damage in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drugs. We enrolled 48 patients with NSTEMI in this study [age, 71.5 years; 61.5/76 (median, 25th/75th percentiles)]. The percentage of total peripheral blood P(+) lymphocytes was elevated owing to the increased frequency of P(+) cells within natural killer (NK) subsets, T and NKT cells in patients on day 1 after NSTEMI when compared with healthy controls. Positive correlations were found between cardiac troponin I plasma concentrations and the frequency of P(+) cells, P(+) T cells, P(+) NK cells and their CD56(+dim) and CD56(+bright) subsets during the first week after the NSTEMI. The expression of P in NK cells was accompanied by P-mediated cytotoxicity against K-562 targets at all days examined, except day 21, when an anti-perforin monoclonal antibody did not completely abolish the killing. The percentage of P(+) T cells, P(+) NKT cells and P(+) NK subsets was the highest on the day 1 after NSTEMI and decreased in the post-infarction period. CD56(+) lymphocytes were found in damaged myocardium, suggesting their tissue recruitment. In conclusion, patients with NSTEMI have a strong and prolonged P-mediated systemic inflammatory reaction, which may sustain autoaggressive reactions towards myocardial tissue during the development of myocardial infarction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|