| Autor: |
Lenka Cagova, Ian S. Scott, Winston Banya, Michael Laffan, Stephane Ledot, Deepa R. J. Arachchillage, Alain Vuylsteke, Hakeem Yusuff, Rachel Jooste, Indika Rajakaruna, Joshua Wade, Lucy Fleming, Graziella Isgro, Mihaela Gaspar, Aikaterini Vlachou |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| Popis: |
COVID-19 is a prothrombotic condition and a major focus of attention has been to reduce thrombosis in order to improve outcomes. Extracorporeal membrane oxygenation (ECMO) triggers contact activation of coagulation, platelet dysfunction and systemic anticoagulation which may contribute to both thrombosis and bleeding complications. Methods: Multicentre observational study of mortality, thrombosis, and bleeding complications in 152 consecutive patients (≥18 years) supported with VV ECMO during the first wave of the COVID-19 pandemic (1st of March 2020 to 31st of May 2020) from four nationally commissioned UK ECMO centres. Findings: Of 152 patients, mortality during ECMO up to 120 days was 21.1% (32/152) whilst overall all cause in- hospital mortality up to 143 days from ECMO initiation was 25.7% (39/152). Median duration on ECMO was 17 days (interquartile range [IQR] 11-29.7). On multivariate analysis, mortality increased with age (Hazard ratio [HR] 1.09 [95% CI 1.03 - 1.14]), P=0.002. Rates of major bleeding and thrombosis during ECMO were 25.0% (38/152) and 17.1% (26/152). Presence of major bleeding prior to or at initiation of ECMO and intracranial haemorrhage during ECMO conferred 3.65 ([95% CI 1.16 - 11.48], P=0.027) and 6.92 ([95% CI 2.66 - 18.02] |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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