Effect of chlorhexidine gluconate mouthrinse on plaque bacteria

Autor: T. E. Sox, E. Grossman, G. F. Rebitski, R. Y. Buckner, R. E. Setser, M. L. Ebert, William W. Briner
Rok vydání: 1986
Předmět:
Zdroj: Journal of Periodontal Research. 21:44-52
ISSN: 1600-0765
0022-3484
DOI: 10.1111/j.1600-0765.1986.tb01514.x
Popis: The antimicrobial effect of a 0.12% chlorhexidine gluconate mouthrinse on plaque bacteria was compared to that of a placebo mouthrinse without chlorhexidine gluconate. Forty subjects in each treatment group rinsed twice daily with 15 ml mouthwash for six months. They were instructed to continue their usual oral hygiene practices. After six months, the subjects stopped using the mouthrinse. Supragingival plaque was collected from each subject and assayed for eight representative microbial populations at baseline, after three and six months of treatment, and after a three-month post-treatment period. During the six months of mouthrinse use, significant reductions in the numbers of total aerobes. total anaerobes, streptococci, and actinomyces were observed in plaque samples taken from subjects using the chlorhexidine mouthrinse. The effect of chlorhexidine on actinomyces accumulation was especially pronounced with reductions ranging from 85–97%. This was considered to be particularly significant since actinomyces is one of the bacteria known to be periodontopathic in both experimental animals and in humans. Although chlorhexidine treatment reduced the number of microbes on teeth, it did not produce a detectable shift in microbial populations. At the end of the three-month post-treatment period, the microbial profile was similar to the pre-treatment profile for both groups. Therefore, no residual effects of chlorhexidine on plaque bacteria were observed after cessation of rinsing.
Databáze: OpenAIRE
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