Estimation of Whole-Body and Appendicular Lean Mass from Spine and Hip Dual Energy X-ray Absorptiometry: A Cross-Sectional Study
Autor: | Mohammadreza Mohebbi, Mark A. Kotowicz, Matthew Thackeray, Julie A. Pasco, Neil Orford |
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Rok vydání: | 2021 |
Předmět: |
musculoskeletal diseases
medicine.medical_specialty medicine.diagnostic_test Cross-sectional study business.industry Endocrinology Diabetes and Metabolism Osteoporosis musculoskeletal system medicine.disease Endocrinology medicine.anatomical_structure Sarcopenia Orthopedic surgery medicine Lean body mass Orthopedics and Sports Medicine business Whole body Nuclear medicine Dual-energy X-ray absorptiometry Femoral neck |
Zdroj: | Calcified Tissue International. 110:341-348 |
ISSN: | 1432-0827 0171-967X |
Popis: | Whole-body dual X-ray absorptiometry (DXA) accurately measures lean mass but is not routinely used in clinical practice. Hip and spine DXA are used in the diagnosis of osteoporosis, and with the common co-occurrence of sarcopenia with osteoporosis, regional DXA scans provide an opportunity for assessment of lean mass. The aim of this study is to develop predictive equations for the estimation of whole-body lean mass (WBLM), appendicular lean mass (ALM) and whole-body fat mass (WBFM) from regional DXA scans. A total of 2427 participants (ages 20–96 year; 57.7% men) from the Geelong Osteoporosis Study who underwent both regional and whole-body DXA were included in the analysis. Using forward stepwise multivariable linear regression, percentage fat (spine%fat, hip%fat) values from lumbar spine and femoral neck DXA were used in combination with clinical data to develop and validate equations for the estimation of WBLM, WBFM and ALM. Mean age was 53.5 year (± 19.2), weight 78.2 kg (± 15.4), height 169.6 cm (± 9.4), WBLM 50.4 kg (± 11.1), ALM 22.8 kg (± 5.4) and WBFM 24.3 kg (± 10.4). Spine%fat (r = 0.21) and hip%fat (r = − 0.34) were correlated with whole-body lean mass (p |
Databáze: | OpenAIRE |
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