Anti‐Tumor Activity of Doxorubicin‐loaded Boehmite Nanocontainers

Autor:	Sara Simonato, Ute Schepers, Claus Feldmann, Eva Zittel, Carmen Seidl
Rok vydání:	2019
Předmět:	Boehmite 010405 organic chemistry Chemistry organic chemicals technology industry and agriculture Nanocontainer macromolecular substances 010402 general chemistry 01 natural sciences In vitro 0104 chemical sciences carbohydrates (lipids) Inorganic Chemistry In vivo Toxicity polycyclic compounds medicine Microemulsion Doxorubicin Drug carrier Nuclear chemistry medicine.drug
Zdroj:	Zeitschrift für anorganische und allgemeine Chemie. 645:1372-1378
ISSN:	1521-3749 0044-2313
DOI:	10.1002/zaac.201900211
Popis:	Doxorubicin-filled boehmite nanocontainers, DOX@γ-AlO(OH), with a mean diameter of 40 nm and a wall thickness of 10 nm are prepared via a microemulsion strategy and studied as drug carriers for cancer treatment. Nanocontainer structure and drug load are examined in detail based on different analytical tools. The DOX load is optimized on highest load at lowest side effects according to blood counts. Cell uptake, DOX-based fluorescence detection and systemic toxicity are evaluated based on in vitro and in vivo models. Toxicity and activity of the DOX@AlO(OH) nanocontainers are compared with non-filled AlO(OH) hollow spheres and free DOX as references and show promising results. An orthotopic breast cancer BALB/c mouse model validates the activity of DOX@AlO(OH) in vivo at lower side effects than for free DOX.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c416ddfd98a389e58bdfcf77e1e96b34 https://doi.org/10.1002/zaac.201900211 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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