Implication of Creatinine and Gut Flora in the Uremic Syndrome: Induction of 'Creatininase' in Colon Contents of the Rat by Dietary Creatinine

Autor:	Philip C. Burnett, James D. Jones
Rok vydání:	1972
Předmět:	medicine.medical_specialty Creatinine Sarcosine biology Methylamine Biochemistry (medical) Clinical Biochemistry Renal function Urine Gut flora biology.organism_classification chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Methylguanidine Creatininase
Zdroj:	Clinical Chemistry. 18:280-284
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/18.3.280
Popis:	"Creatininase" activity was induced in the colon flora of rats by feeding creatinine. Sarcosine and methylamine were tentatively identified as the major products of the enzymic action. A third (unidentified) compound was observed. These compounds and methylguanidine were labeled in the urine of rats given 14CH3-creatinine orally. The results suggest that creatinine should not be considered biologically inert in animals, especially in those with decreased renal function.
Databáze:	OpenAIRE
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