Effect of kauranes from Montanoa spp. on rat uterus

Autor:	Antonio Valencia-Sánchez, Héctor Ponce-Monter, Lidia Osuna, Carmen Uribe, Patricia Campos-Bedolla, María G. Campos, José Nieto Calderón
Rok vydání:	1997
Předmět:	Pharmacology medicine.medical_specialty biology Montanoa tomentosa Montanoa Uterus biology.organism_classification medicine.anatomical_structure Endocrinology Mechanism of action Oxytocin Internal medicine medicine Serotonin medicine.symptom Receptor Acetylcholine medicine.drug
Zdroj:	Phytotherapy Research. 11:11-16
ISSN:	0951-418X
DOI:	10.1002/(sici)1099-1573(199702)11:1<11::aid-ptr936>3.0.co;2-v
Popis:	The effect of kaurenoic acid (from Montanoa frutescens), grandifloric and kauradienoic acid (from M. tomentosa) and 16α-hydroxy-ent-kauran-19-oic acid and its methyl ester (from M. hibiscifolia) were assayed on the contractions of rat uterus induced by acetylcholine, oxytocin and serotonin. The four kauranes assayed inhibited the contractile activity induced by the three agonists through a mechanism independent of either β2-adrenergic or H2-histaminergic receptors present in uterine smooth muscle. Oestrogenized uteri treated with kauradienoic acid underwent histological changes including epithelial flattening and desquamation.© 1997 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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