Alterations of creatine kinase isoenzymes in colon washings from patients with colonic and rectal diseases

Autor: Albert Weinstock, Sung-Tao Ko, Otto E. Lobstein, Simon Bereznitsky
Rok vydání: 1982
Předmět:
Zdroj: Cancer. 50:1177-1180
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(19820915)50:6<1177::aid-cncr2820500624>3.0.co;2-b
Popis: Mucus samples obtained from 61 patients with different types of colon and rectal disease were assayed for CK isoenzyme fractionation. Twelve additional patients without evidence of such diseases were used as reference subjects. The diseases surveyed were hemorrhoids, proctocolitis, polyps, and cancer of the colon and rectum. The CK BB fraction was predominant in the mucus of the reference subjects and in mild cases of hemorrhoids and polyps. With inflammation of degeneration of the colonic mucosa, the present CK BB decreased and the percent of CK MM increased. It is speculated that the increased CK MM possibly derives from increased permeability of degeneration of the colonic wall, permitting plasma CK MM to admix with the mucus. Mucin CK isoenzyme fractionation may be useful in assessing the pathogenesis of colonic and rectal diseases, as a marker to monitor the efficacy of the therapeutic regimen, and as a technique for monitoring conversion of a premalignant process into a malignant one.
Databáze: OpenAIRE
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