99mTc-labeling of mercaptoacetyltriglycine and its related compounds
| Autor: | J. Környei, J. Törkő, J. Volford |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Sulfonyl
chemistry.chemical_classification Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Tripeptide Ligand (biochemistry) Pollution Combinatorial chemistry Analytical Chemistry Renal agents Nuclear Energy and Engineering chemistry Radiology Nuclear Medicine and imaging Spectroscopy Nuclear chemistry |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry Letters. 186:189-197 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | Mercaptoacetyltriglycine and its related compounds were synthesized and labeled with99mTc-radionuclide in order to study the effect of substituents and labeling conditions upon the formation of radioactive by-products. Direct labeling and ligand exchange reactions were followed by radio-TLC separation. The direct labeling in alkaline media at elevated temperature provides high radiochemical yields and gives opportunity for a new kit formulation because the neutralization to physiological pH does not cause any change in the chemical identity of the complexes. Compounds with the strongly polar sulfonyl groups show significantly lower protein binding compared with mercaptoacetyltriglycine and may be considered as potential renal agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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