Prevalence of cognitive impairment before treatments for prostate cancer
| Autor: | J Oliveira, Nuno Lunet, Ana C. Costa, Susana Pereira, F Carneiro, Luisa Lopes-Conceição, A Ferreira, Luis Ruano, Natália Araújo, Samantha Morais |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry medicine.medical_treatment Public Health Environmental and Occupational Health Montreal Cognitive Assessment Cancer Cognition medicine.disease Chemotherapy regimen Radiation therapy Prostate cancer Internal medicine medicine P-Chloroamphetamine Cognitive impairment business |
| Zdroj: | European Journal of Public Health. 31 |
| ISSN: | 1464-360X 1101-1262 |
| Popis: | Background/Objective Up to 30% of patients with cancer may present cognitive impairment (CI) before treatment but data are scarce regarding prostate cancer (PCa). We aim to estimate the prevalence of CI in patients with PCa, before cancer treatment. Methods Between February 2018 and April 2021, the NEON-PC cohort included 609 patients with a recent PCa diagnosis to be treated at Instituto Português de Oncologia do Porto. Previous history of chemotherapy, radiotherapy, androgen deprivation therapy, and neurologic or psychyatric conditions impairing cognitive performance were exclusion criteria. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive performance before any treatment for PCa. Participants with a MoCA at least 1.5 SD below age- and education-specific norms were considered to have probable cognitive impairment (PCI) and were proposed for a comprehensive neuropsychological (NP) assessment. Participants scoring Results/Discussion Prevalence of PCI was 17.4% in the EPIPorto and 15.1% in the NEON-PC cohort (age- and education-adjusted OR = 1.02,95% confidence interval: 0.70,1.50). NP assessment was performed in 65 patients with PCa: 38.5% had normal cognitive function; 7.7% had a light deficit ( Conclusions PCI was as frequent in patients recently diagnosed with PCa as in the general population. Prevalence of CI was lower than in previous reports, which may be explained by differences in the assessment and definition of CI and of the type of cancer. Funding POCI-01-0145FEDER-032358;PTDC/SAU-EPI/32358/2017;UIDB/4750/2020; SFRH/BD/119390/2016 Key messages Patients with prostate cancer and the general population had similar odds of having a score below normative values in the MoCA. Differences in the prevalence of CI between this study and others suggest that the type of cancer may affect patients’ cognitive performance differently, which deserves further confirmation. |
| Databáze: | OpenAIRE |
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