Rutin improves endotoxin-induced acute lung injury via inhibition of iNOS and VCAM-1 expression
| Autor: | Chi-Ting Horng, Shiuan-Shinn Lee, Chung-Hsin Yeh, Ming-Ling Yang, Shyan-Tarng Chen, Chien-Ying Lee, Yu-Hsiang Kuan, Yi-Chun Huang, Wu-Hsien Kuo |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Lipopolysaccharide business.industry Health Toxicology and Mutagenesis General Medicine Management Monitoring Policy and Law Lung injury Toxicology medicine.disease Sepsis 03 medical and health sciences chemistry.chemical_compound Rutin 030104 developmental biology chemistry Immunology Medicine VCAM-1 business Beneficial effects Infiltration (medical) |
| Zdroj: | Environmental Toxicology. 31:185-191 |
| ISSN: | 1520-4081 |
| DOI: | 10.1002/tox.22033 |
| Popis: | Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins in many serious diseases, such as fever, sepsis, multi-organ failure, meningococcemia, and severe morbidities like neurologic disability, or hearing loss. Endotoxins are also called lipopolysaccharide (LPS) and are important pathogens of acute lung injury (ALI). Rutin has potential beneficial effects including anti-inflammation, antioxidation, anti-hyperlipidemia, and anti-platelet aggregation. Pre-treatment with rutin inhibited LPS-induced neutrophil infiltration in the lungs. LPS-induced |
| Databáze: | OpenAIRE |
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