Pd-catalyzed asymmetric oxidative C-H/C-H cross-coupling reaction between dialkylaminomethylferrocenes and indolizines

Autor:	Fangnuo Zhao, Zuolijun Feng, Chen-Xu Liu, Quannan Wang, Su-Zhen Zhang, Shu-Li You, Wen-Wen Zhang, Pusu Yang, Qing Gu
Rok vydání:	2022
Předmět:	Organic Chemistry Enantioselective synthesis Regioselectivity chemistry.chemical_element Planar chirality Combinatorial chemistry Coupling reaction Catalysis chemistry.chemical_compound Ferrocene chemistry Chemistry (miscellaneous) Reactivity (chemistry) Physical and Theoretical Chemistry Palladium
Zdroj:	Chem Catalysis. 2:102-113
ISSN:	2667-1093
Popis:	Summary Oxidative C-H/C-H cross-coupling reactions between two (hetero)arenes through 2-fold C-H activation offer rapid assembly of diverse bi(hetero)aryls. Herein, a Pd-catalyzed asymmetric oxidative C-H/C-H cross-coupling reaction of ferrocenes with indolizines was disclosed. A palladium(II)/monoprotected amino acid (MPAA) catalytic system exhibited excellent reactivity, regioselectivity, and enantioselectivity for the coupling reaction. This approach marks the first example of direct arylation of indolizines in an enantioselective oxidative C-H/C-H cross-coupling process and offers a powerful strategy for the synthesis of highly enantioenriched planar chiral ferrocenes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3d7efa0df50c36ce8cdc721b92b7a3b https://doi.org/10.1016/j.checat.2021.11.001 Zobrazit plný text záznamu