A Comparison of the Electric Potential through the Membranes of Ganglion Neurons and Neuroblastoma Cells

Autor:	Thiago M. Pinto, Roseli S. Wedemann, Célia Martins Cortez
Rok vydání:	2011
Předmět:	Glycocalyx Electrophoresis Membrane medicine.anatomical_structure Cytoplasm Chemistry Neuroblastoma medicine Biophysics Electric potential Neuron medicine.disease Ganglion
Zdroj:	Lecture Notes in Computer Science ISBN: 9783642217371 ICANN (2)
Popis:	We have modeled the electric potential profile, across the membranes of the ganglion neuron and neuroblastoma cells. We considered the resting and action potential states, and analyzed the influence of fixed charges of the membrane on the electric potential of the surface of the membranes of these cells, based on experimental values of membrane properties. The ganglion neuron portrays a healthy neuron, and the neuroblastoma cell, which is tumorous, represents a pathologic neuron. We numerically solved the non-linear Poisson-Boltzmann equation, by considering the densities of charges dissolved in an electrolytic solution and fixed on both glycocalyx and cytoplasmic proteins. We found important differences among the potential profiles of the two cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3d65487c658555df3d4bb42870fde6d https://doi.org/10.1007/978-3-642-21738-8_14 Zobrazit plný text záznamu