Background neuronal activity in thenucleus supraopticus and its modifications under the influence of parathyroid hormone
| Autor: | K. G. Bagdasaryan, P. Sh. Sarkisyan, D. N. Khudaverdyan, A. A. Asratyan |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
CATS Physiology Chemistry General Neuroscience Spike train Parathyroid hormone medicine.anatomical_structure Endocrinology Hypothalamus Internal medicine medicine Premovement neuronal activity Temporal organization Nucleus hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Neurophysiology. 31:330-335 |
| ISSN: | 1573-9007 0090-2977 |
| DOI: | 10.1007/bf02515115 |
| Popis: | In experiments on anesthetized cats, we found that i. v. injection of 5.0 U/kg of parathyroid hormone (PTH) results in modifications of the statistical parameters of the neuronal impulse activity in thenucleus supraopticus (SO) of the hypothalamus. Sliding frequency graphs, histograms of interspike intervals, autocorrelograms, and serial correlation coefficients were plotted and calculated before and after PTH injections; their comparison demonstrates that the hormone significantly modulates the temporal organization of spike trains generated by the neurons of this nucleus. We observed that PTH mostly activated SO neurons and diminished the level of spike grouping in their activity. The effect of PTH to a certain level depended on the initial frequency of background activity: an increase in the spiking frequency was typical of primarily dominating “low-frequency” neurons, while “high-frequency” units were mostly inhibited. The possible mechanisms of the observed modifications are discussed. |
| Databáze: | OpenAIRE |
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