Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Autor:	Shinsuke Inuki, Takanori Matsumaru, Ryosuke Yamaguchi, Keisuke Sato, Naoto Zui, Yukari Fujimoto
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Innate immune system chemistry Stereochemistry Organic Chemistry TLR4 Side chain Moiety chemistry.chemical_element Receptor Alkyl Catalysis Palladium
Zdroj:	The Journal of Organic Chemistry. 84:12680-12685
ISSN:	1520-6904 0022-3263
Popis:	FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3c84f090f2507d5002c779ff8c208b1 https://doi.org/10.1021/acs.joc.9b02101 Zobrazit plný text záznamu