Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety
Autor: | Shinsuke Inuki, Takanori Matsumaru, Ryosuke Yamaguchi, Keisuke Sato, Naoto Zui, Yukari Fujimoto |
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Rok vydání: | 2019 |
Předmět: | |
Zdroj: | The Journal of Organic Chemistry. 84:12680-12685 |
ISSN: | 1520-6904 0022-3263 |
Popis: | FNC-RED exhibits innate immune receptor Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD2) stimulatory activity. We have developed a divergent synthetic route to FNC-RED derivatives containing various alkyl side chains. Key features of the synthetic study include stepwise palladium catalyzed cross-coupling reactions and the construction of an all syn-cyclopentanetetrol moiety. |
Databáze: | OpenAIRE |
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