Catalyst-free one-pot cascade cyclization: An efficient synthesis of isoindolobenzoxazinones and isoindoloquinazolinones derivatives

Autor:	Fangzhen Wang, Wei-Li Wang, Baibai Wan, Jiazhu Li, Wenzhong Li, Xin-Ming Xu, Ran Shi, Hexu Niu, Si Chen
Rok vydání:	2022
Předmět:	inorganic chemicals Cascade Chemistry Organic Chemistry Drug Discovery Substrate (chemistry) Biochemistry Combinatorial chemistry Catalysis
Zdroj:	Tetrahedron. 104:132571
ISSN:	0040-4020
Popis:	A practical and efficient catalyst-free cascade cyclization reaction of 2-acylbenzoic acids with various amino alcohols or diamines was developed. This protocol provides a powerful and straightforward method for the one-pot synthesis of diverse isoindolobenzoxazinones, isoindoloquinazolinones and their derivatives. The synthetic strategy evades the use of catalyst, shows a broad substrate scope and could be performed in gram-scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3b62b89f5fd06dc81f246874e340e8f https://doi.org/10.1016/j.tet.2021.132571 Zobrazit plný text záznamu Full Text from ScienceDirect