Tumor Aggressiveness and Patient Outcome in Cancer of the Pancreas Assessed by Dynamic 18F-FDG PET/CT
| Autor: | Ora Israel, Ron Epelbaum, Riad Haddad, Natalia Sikorski, Ludwig G. Strauss, Alex Frenkel, Antonia Dimitrakopoulou-Strauss |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Cancer Blood volume medicine.disease medicine.anatomical_structure Pancreatic cancer Localized disease Pancreatectomy medicine Adenocarcinoma Radiology Nuclear Medicine and imaging Fdg pet ct Radiology Pancreas Nuclear medicine business |
| Zdroj: | Journal of Nuclear Medicine. 54:12-18 |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.112.107466 |
| Popis: | This study aimed to assess the role of a quantitative dynamic PET model in pancreatic cancer as a potential index of tumor aggressiveness and predictor of survival. Methods: Seventy-one patients with 18F-FDG–avid adenocarcinoma of the pancreas before treatment were recruited, including 27 with localized tumors (11 underwent pancreatectomy, and 16 had localized nonresectable tumors) and 44 with metastatic disease. Dynamic 18F-FDG PET images were acquired over a 60-min period, followed by a whole-body PET/CT study. Quantitative data measurements were based on a 2-compartment model, and the following variables were calculated: VB (fractional blood volume in target area), K1 and k2 (kinetic membrane transport parameters), k3 and k4 (intracellular 18F-FDG phosphorylation and dephosphorylation parameters, respectively), and 18F-FDG INF (global 18F-FDG influx). Results: The single significant variable for overall survival (OS) in patients with localized disease was 18F-FDG INF. Patients with a high 18F-FDG INF (>0.033 min−1) had a median OS of 6 and 5 mo for nonresectable and resected tumors, respectively, versus 15 and 19 mo for a low 18F-FDG INF in nonresectable and resected tumors, respectively (P |
| Databáze: | OpenAIRE |
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