Decorporation of Polonium from Rats by New Chelating Agents
| Autor: | V. Volf, M.M. Jones, P.K. Singh, J. Rencová |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
chemistry.chemical_classification
Radiation Radiological and Ultrasound Technology Chemistry medicine.medical_treatment Public Health Environmental and Occupational Health chemistry.chemical_element General Medicine Toxicology Thiol medicine Radiology Nuclear Medicine and imaging Chelation Antidote Dithiocarbamate Nuclear chemistry Polonium |
| Zdroj: | Radiation Protection Dosimetry. 53:311-313 |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/rpd/53.1-4.311 |
| Popis: | The effectiveness of newly synthesised thiol chelating agents has been studied to reduce 210 Po in organs and tissues of rats. From four derivatives of meso-2,3-dimercaptosuccinic acid (DMSA) only the ethoxyethyl diester (DEEDMS) was efficient in decreasing total activity in the analysed tissues (to 80% of control animals) when repeated subcutaneous treatment started 1 h after intravenous injection of 210 Po. The most pronounced effect was achieved with three derivatives of dithiocarbamate: N,N'-dimethyl-(MeTTC), N,N'-diethyl-(EtTrC), N,N'-di(2-hydroxyethyl)ethylenediamine-N,N'-bisdithiocarbamate (HOEtTTC). When treatment started immediately after 210 Po administration, the total content of 210 Po in analysed tissues was reduced to 74-41% of control values |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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