Endocannabinoids and stress-related disorders: A systematic review of basal levels and responses to acute psychosocial stress
| Autor: | MacKenna Marie Shampine, Mayo, Leah, Barcelona, Jeanne, Carpenter, Carmen, Gowatch, Leah, Ely, Samantha, Zundel, Clara, Marusak, Hilary A., Evanski, Julia, Bhogal, Amanpreet |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
Medical Sciences
Neuroscience and Neurobiology 2-AG Physiology FOS: Clinical medicine Biological Psychology Neurosciences Life Sciences PTSD endocannabinoid Social and Behavioral Sciences anxiety Cellular and Molecular Physiology FOS: Psychology stress posttraumatic stress disorder FOS: Biological sciences depression Medicine and Health Sciences Psychology anandamide psychosocial stress |
| DOI: | 10.17605/osf.io/72z9h |
| Popis: | The endocannabinoid (eCB) system plays a key role in regulating stress. Dysregulation of the eCB system is implicated in stress-related neuropsychiatric disorders (e.g., anxiety, depression, PTSD). Despite optimism that eCBs may be a potential biomarker for stress-related disorders and target for intervention, results have been inconsistent across studies. This project will systematically review the literature on the role of eCBs—specifically anandamide (AEA) and 2-Arachidonoylglycerol (2-AG)—at rest or in response to acute psychosocial stress in individuals with and without stress-related disorders (SRDs). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|