Membranotropic and relaxation properties of water-soluble gadolinium endometallofullerene derivatives

Autor:	D. A. Poletaeva, A. B. Kornev, R. A. Kotel’nikova, I. I. Faingold, V. S. Romanova, Pavel A. Troshin, V. P. Bubnov, Ivan E. Kareev, Alexander I. Kotelnikov
Rok vydání:	2014
Předmět:	Gadolinium MRI contrast agent Relaxation (NMR) Membrane structure chemistry.chemical_element General Chemistry Microviscosity chemistry.chemical_compound Nuclear magnetic resonance Membrane chemistry Proton NMR Biophysics Pyrene
Zdroj:	Russian Chemical Bulletin. 63:1107-1112
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-014-0556-0
Popis:	The membranotropic and relaxation properties of novel water-soluble gadolinium endometallofullerene derivatives (EMFD) were studied. Localization of EMFD in membranes and EMFD-induced changes in the membrane structure were determined by measuring the emission quenching of pyrene as a fluorescent probe. It was demonstrated that EMFD efficiently interact with pyrene molecules in model membranes, thus changing their microviscosity. Pulsed 1H NMR experiments revealed that the hydroxylated endometallofullerene Gd@C82(OH)∼30 has the highest relaxivity (R1 = 7.390 L mol−1 s−1) among the test EMFD and that its efficiency is 3.6 times that of the commercial MRI contrast agent Magnevist. The data obtained suggest that these EMFD are promising for use as low-toxicity contrast agents for magnetic resonance imaging.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3aa90d1f71ebaea1db161f6466b961c https://doi.org/10.1007/s11172-014-0556-0 Zobrazit plný text záznamu Full text from SpringerLink