| Autor: |
Raquel Almansa, Felipe Pérez-García, P. Olivares, José María Eiros, Ruben Herran, Jamil Antonio Cedeno, Anna Motos, Antoni Torres, Ferran Barbé, Salvador Resino, Marta Domínguez-Gil, Alicia Ortega, Gloria Renedo, Mónica Herrero Vázquez, Milagros González-Rivera, Amanda de la Fuente, María José Muñoz-Gómez, Elena Bustamante, Ricard Ferrer, Laia Fernández-Barat, María Martín-Vicente, Nuria Mamolar, Carolina Puertas, Jesus F. Bermejo-Martin, Jose Ángel Berezo, Cesar Aldecoa, Juan Bustamante-Munguira, Ana P. Tedim, Isidoro Martínez, Noelia Jorge, Jesús Rico-Feijoo, David J. Kelvin, Pedro Enriquez, Luis Tamayo, Vicente Mas, Ramón Cicuendez, José Manuel Gómez, Silvia Martín |
| Rok vydání: |
2021 |
| Předmět: |
|
| Popis: |
Purposeto evaluate the association between anti-SARS-CoV-2 S IgM and IgG antibodies with viral RNA load in plasma, the frequency of antigenemia and with the risk of mortality in critically ill patients with COVID-19.Methodsanti-SARS-CoV-2 S antibodies levels, viral RNA load and antigenemia were profiled in plasma of 92 adult patients in the first 24 hours following ICU admission. The impact of these variables on 30-day mortality was assessed by using Kaplan-Meier curves and multivariate Cox regression analysis.Resultsnon survivors showed more frequently absence of anti-SARS-CoV-2 S IgG and IgM antibodies than survivors (26.3% vs 5.6% for IgM and 18.4% vs 5.6% for IgG), and a higher frequency of antigenemia (47.4% vs 22.2%) (p p]: [S IgM (AUC ≥60): 0.48 (0.24; 0.97), 0.040]; [S IgG (AUC ≥237): 0.47 (0.23; 0.97), 0.042]; [Antigenemia (+): 2.45 (1.27; 4.71), 0.007]; [N1 viral load (≥ 2.156 copies/mL): 2.21 (1.11; 4.39),0.024]; [N2 viral load (≥ 3.035 copies/mL): 2.32 (1.16; 4.63), 0.017]. Frequency of antigenemia was >2.5-fold higher in patients with absence of antibodies. Levels of anti-SARS-CoV-2 S antibodies correlated inversely with viral RNA load.Conclusionabsence / insufficient levels of anti-SARS-CoV-2 S antibodies following ICU admission is associated to poor viral control, evidenced by increased viral RNA loads in plasma, higher frequency of antigenemia, and also to increased 30-day mortality.Take-home messageabsent or low levels of antibodies against the S protein of SARS-CoV- 2 at ICU admission is associated to an increased risk of mortality, higher frequency of antigenemia and higher viral RNA loads in plasma. Profiling anti-SARS-CoV-2 s antibodies at ICU admission could help to predict outcome and to better identify those patients potentially deserving replacement treatment with monoclonal or polyclonal antibodies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
