Superoxide radical and nephrotoxic effect of cadmium exposure
| Autor: | Ana Sofia Rodrigues, Ethel L. B. Novelli, Jose Luiz V. B. Novelli Filho, B. O. Ribas, Ana M. Lopes |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification Reactive oxygen species Cadmium Lipid peroxide Health Toxicology and Mutagenesis Glutathione peroxidase Public Health Environmental and Occupational Health chemistry.chemical_element General Medicine Pharmacology Cadmium chloride Pollution Nephrotoxicity chemistry.chemical_compound chemistry Biochemistry Toxicity Environmental toxicology |
| Zdroj: | International Journal of Environmental Health Research. 9:109-116 |
| ISSN: | 1369-1619 0960-3123 |
| DOI: | 10.1080/09603129973245 |
| Popis: | Pollution and industrial practices result in concentrations of metals and other environmental agents that are related to environmental toxicity. Concentrations of metals are widely related to biochemicals values which are used in disease diagnosis due to environmental toxicity. This work was carried out in order to verify the nephrotoxic effect of cadmium and to clarify the contribution of reactive oxygen species (ROS) in this process. Cadmium chloride was tested for nephrotoxic damage in rats by a single intraperitoneal (i.p.) injection Cd2+ (2 mg/kg) and oral intake (Cd2+ -100mg/l-from CdCl2). The cadmium-induced biochemical alterations included significant increased levels of serum creatinine concentrations, in rats with i.p. injection. Total urinary protein concentrations were only increased in rats with cadmium intake. Lipoperoxide was also increased after 3 and 7 days of the Cd2+ treatment. No changes were observed in glutathione peroxidase activities. Cadmium-induced damage might be due to superoxi... |
| Databáze: | OpenAIRE |
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