A rare case of generalized tonic‐clonic seizure related to paclitaxel infusion

Autor:	Olisa Ezegwu, Nair Renu, Oyintayo Ajiboye, Muhammed Talha Ayub, Ishaan Vohra
Rok vydání:	2019
Předmět:	Pharmacology Oncology medicine.medical_specialty Chemotherapy Lung business.industry medicine.medical_treatment Central nervous system medicine.disease Blood–brain barrier 030226 pharmacology & pharmacy Hypersensitivity reaction 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure Paclitaxel chemistry Internal medicine medicine Pharmacology (medical) 030212 general & internal medicine Sarcoma business Adverse effect
Zdroj:	Journal of Clinical Pharmacy and Therapeutics. 44:974-976
ISSN:	1365-2710 0269-4727
DOI:	10.1111/jcpt.13027
Popis:	What is known and objective Paclitaxel (Taxol) is an antineoplastic agent approved in the United States for the treatment of lung, breast, cervical, pancreatic cancers and Kaposi sarcoma. Paclitaxel does not cross the blood brain barrier, so central nervous system adverse effects are uncommon. Case description We describe a 60-year-old woman with Stage IIIa squamous cell carcinoma of the left lung, who developed a generalized tonic-clonic seizure during her first infusion of paclitaxel. What is new and conclusion Seizure related to a hypersensitivity reaction from paclitaxel infusion are rare but could be life-threatening and require immediate recognition, treatment and exclusion of other possible aetiologies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c38e68e244c9b393ef9db7e34f85ff8a https://doi.org/10.1111/jcpt.13027 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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