ChemInform Abstract: Nitrosation of 2-Aryl-1,1-dibromocyclopropanes: Synthesis of 3-Aryl-5-bromoisoxazoles

Autor:	Pavel A. Danilov, Aleksandr A. Vinogradov, Anna Yu. Gavrilova, Nikolai V. Zyk, S. N. Nikolaeva, Oksana B. Bondarenko
Rok vydání:	2016
Předmět:	chemistry.chemical_compound chemistry Aryl Nitrosation Sulfur trioxide Regioselectivity Nitrosyl chloride General Medicine Medicinal chemistry
Zdroj:	ChemInform. 47
ISSN:	0931-7597
Popis:	An efficient transformation of 2-aryl-1,1-dibromocyclopropanes under the action of sulfur trioxide activated nitrosyl chloride has been developed, providing a series of arylated 5-bromoisoxazoles with good yields. It is noteworthy that under the reported conditions the nitrosation–heterocyclization reaction proceeded with high regioselectivity leading exclusively to 3-aryl-5-bromoisoxazoles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c383f7a2134663599f12e66827ef051a https://doi.org/10.1002/chin.201612155 Zobrazit plný text záznamu Plný text