Peripheral Neuropathy Associated With Immunoglobulin Disorders An Immunological and Ultrastructural Study

Autor:	G. Tridente, E. Nardelli, S. Pizzighella, Nicolo' Rizzuto
Rok vydání:	1981
Předmět:	Pathology medicine.medical_specialty Nerve biopsy Immunoperoxidase medicine.diagnostic_test biology business.industry medicine.disease Immunoglobulin light chain Peripheral Peripheral neuropathy nervous system Gammopathy biology.protein Ultrastructure Medicine Antibody business
Zdroj:	Experimental and Clinical Neuropathology ISBN: 9783540104490
DOI:	10.1007/978-3-642-81553-9_76
Popis:	Light-, electron microscopic and immunopathological findings in a nerve biopsy of a patient with peripheral neuropathy associated with monoclonal gammopathy are reported. Loss of fibers, Wallerian-like degeneration and segmental demyelination were the most important features observed in light microscopy. In E.M. widening of the peripheral lamellae of myelin sheaths and occasional aspects of hypermyelination were seen. Immunoperoxidase study showed binding of IgM (k light chain) on the myelin sheath. The possible pathogenetic implications of these findings are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c37ed9260f6ed79059b1a98b4379915f https://doi.org/10.1007/978-3-642-81553-9_76 Zobrazit plný text záznamu