Quantitative analysis for tricyclic antidepressant drugs in plasma or serum by gas chromatography-chemical-ionization mass spectrometry

Autor:	M A Peat, Thomas A. Jennison, G W Thatcher, D M Chinn, D J Crouch
Rok vydání:	1980
Předmět:	Chemical ionization Potassium hydroxide chemistry.chemical_compound Chromatography Chemistry Standard addition Biochemistry (medical) Clinical Biochemistry Extraction (chemistry) Tricyclic antidepressant drugs Gas chromatography Plasma Quantitative analysis (chemistry)
Zdroj:	Clinical Chemistry. 26:1201-1204
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/26.8.1201
Popis:	We describe a gas chromatographic-chemical-ionization mass spectrometric procedure for determining concentrations of the tricyclic antidepressant drugs and their demethylated metabolites in plasma. The procedure requires 2.0 mL of plasma or serum and involves internal standard addition, extraction with a mixed organic solvent, and separation on a column packed with 0.5% potassium hydroxide and 2% Carbowax 20M. Between-assay and within-assay (n = 10) CVs were less than 11.0%. The procedure has been applied to several interesting cases, three of which are summarized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c37ed369f06f86b3139ba39f68260136 https://doi.org/10.1093/clinchem/26.8.1201 Zobrazit plný text záznamu