Investigation of SR-BI gene rs4238001 and rs5888 polymorphisms prevalence and effects on Turkish patients with metabolic syndrome
| Autor: | Kamile Marakoğlu, Mehmet Filizfidan, Burcu Çaykara, Hani Alsaadoni, Nisa Çetin Kargın, Sadrettin Pence, Halime Hanım Pençe |
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| Rok vydání: | 2019 |
| Předmět: |
business.industry
Turkish Biochemistry (medical) Clinical Biochemistry 030204 cardiovascular system & hematology medicine.disease Bioinformatics Biochemistry language.human_language 03 medical and health sciences 0302 clinical medicine medicine language 030211 gastroenterology & hepatology Metabolic syndrome business Molecular Biology Gene |
| Zdroj: | Turkish Journal of Biochemistry. 45:435-441 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2018-0499 |
| Popis: | Aim Metabolic syndrome (MS) is associated with dyslipidemia such as hypertriglyceridemia and high-density lipoprotein (HDL) levels. Scavenger receptor BI (SR-BI) is the transmembrane receptor that regulates selective intake of cholesterol esters by the liver and it binds to HDL with high affinity. This study was aimed to determine the effects of SR-BI gen variations upon proatherogenic and antiatherogenic lipid profiles in the patients with metabolic syndrome. Methods The patient group was consisted of 104 (30–65 years) male subjects who were diagnosed with MS and 100 healthy male subjects were included in control group. DNA was isolated from blood samples. SR-BI gene rs4238001 and rs5888 variants were examined by SNaPshot multiplexing system. SPSS 18 was used for statistical analysis and p Results It was found that SR-BI gene rs4238001 T allele increased the risk of metabolic syndrome 1.61 fold (p=0.02). Subjects with TT genotype 2.847 fold increased the risk of metabolic syndrome according to subjects with CC genotype (p=0.017). Conclusions SR-BI rs4238001 variation may be related to an increased risk of metabolic syndrome. |
| Databáze: | OpenAIRE |
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