Effect of Hyperthermia on Proteases and Growth Regulators in the Skeletal Muscle of Cultivated Rainbow Trout O. mykiss
| Autor: | N. P. Kantserova, M. A. Rodin, M. V. Churova, Ekaterina Tushina, M. Yu. Krupnova, Irina Sukhovskaya, L. A. Lysenko |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
biology 010405 organic chemistry Myogenesis Chemistry Organic Chemistry Skeletal muscle Myostatin Protein degradation biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Cell biology 03 medical and health sciences Trout 030104 developmental biology medicine.anatomical_structure Myosin medicine biology.protein Rainbow trout Myofibril |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 46:1181-1186 |
| ISSN: | 1608-330X 1068-1620 |
| DOI: | 10.1134/s1068162020060114 |
| Popis: | The expression of some structural and regulatory muscle protein genes as well as the activity of the main intracellular proteases (calpains, proteasomes) in caged rainbow trout in the periods favorable for growth and under hyperthermia were estimated. Intense growth of fish was accompanied by high transcriptional activity of the myosin heavy chain (MyHC) gene with the constraining influence of myostatin, high protein turnover rate, and stable levels of myogenic factors, MyoG and MyoD1b. Trout growth retardation in response to summer increase in water temperature was associated with a decrease in gene expression of the main protein of myofibrils, myosin. In hyperthermia, proteolytic activity of calpains and proteasomes, which determine the level of protein degradation in muscle and thereby regulate the intensity of protein accumulation and overall growth, also decreased. Thus, changes in the intensity of myofibrillar protein synthesis, myogenesis, and protein degradation in rainbow trout during periods favorable for growth and under hyperthermia occur in a coordinated manner indicating a relationship of these processes. |
| Databáze: | OpenAIRE |
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