Conducting Polymer-based Aptamer Biosensor for in situ Monitoring of Cytokine

Autor:	Bradly Randall, Xinyan Tracy Cui, Nicolas Alexander Alba, Wei Liao
Rok vydání:	2007
Předmět:	In situ Conductive polymer chemistry.chemical_compound Cytokine Materials science chemistry medicine.medical_treatment Aptamer medicine Nanotechnology Polypyrrole Biosensor Dielectric spectroscopy
Zdroj:	MRS Proceedings. 1065
ISSN:	1946-4274 0272-9172
DOI:	10.1557/proc-1065-qq05-05
Popis:	Neural prostheses often suffer from undesired chronic inflammatory tissue response. Therefore; a sensitive and real-time biosensor for inflammatory cytokine detection would provide invaluable information toward solving this problem. Such a biosensor based on an aptamer probe doped in polypyrrole and subsequent electrochemical impedance spectroscopy (EIS) has been developed. PDGF, an important inflammatory cytokine, has been successfully measured in both offline EIS characterization and real-time impedance monitoring. For in situ detection of PDGF, the best sensitivity of 10 ng/ml has been achieved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c3783062af6d953bd60eb6d166d6c889 https://doi.org/10.1557/proc-1065-qq05-05 Zobrazit plný text záznamu Full text from SpringerLink